Neural circuit hacking by global aminergic-silencing and partial rescues (add-back)..

Wednesday, October 24, 2012 – 17 views

— by balapagos

Interesting new research article:

The approach is summarized here:

"The requirement of DVMAT [Drosophila Vesicular MonoAmine Transporter] for normal exocytotic transmitter release in all central aminergic neurons-- rather than a single subset-- presents a unique opportunity for ablating normal synaptic transmission in all aminergic systems simultaneously then adding back each one in isolation or in combination. Thus, starting with a loss of function dVMAT mutant background, we have systematically added back, or genetically rescued, DVMAT function and vesicular release in specific subsets of aminergic neurons."

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